Methamphetamine

filed under | drugs

Share/Bookmark

Methamphetamine enters the brain and triggers a cascading release of dopamine and norepinephrine. It is highly active in the mesolimbic reward pathways of the brain, inducing intense euphoria, with a high potential for addiction. To a lesser extent, methamphetamine releases serotonin and acts as a dopaminergic and adrenergic reuptake inhibitor with higher concentrations serving as a monoamine oxidase inhibitor. Users may become hypersexual or obsessed with a task, thought or activity. Withdrawal is characterized by excessive sleeping, eating, and depression, often accompanied by anxiety and drug-craving. Methamphetamine users may take sedatives such as benzodiazepines as a means of easing their comedown, anxiety, or difficulty sleeping. Physical effects can include anorexia, hyperactivity, dilated pupils, flushing, restlessness, dry mouth, headache, tachycardia, bradycardia, tachypnea, hypertension, hypotension, hyperthermia, diaphoresis, diarrhea, constipation, blurred vision, dizziness, muscle twitches, insomnia, numbness, palpitations, arrhythmias, tremors, dry and/or itchy skin, acne, pallor, and with chronic and/or high dosages, convulsions, heart attack, stroke, and death can occur. The half life of methamphetamine is 915 hours. It is excreted by the kidneys and its half life depends on urinary pH. Methamphetamine users and addicts may lose their teeth abnormally quickly, a condition known as "meth mouth". This effect is not caused by any corrosive effects of the drug itself, which is a common myth. According to the American Dental Association, meth mouth is probably caused by a combination of drug-induced psychological and physiological changes resulting in xerostomia (dry mouth), extended periods of poor oral hygiene, frequent consumption of high-calorie, carbonated beverages and bruxism (teeth grinding and clenching). [READ THE REST OF THIS ARTICLE]





wikisnap.com is not affiliated with or endorsed by wikipedia. wikipedia and the wikipedia globe are registered trademarks of wikipedia.org.
article content reproduced in compliance with wikipedia's copyright policy and gnu free documentation license
view our privacy policy and terms of service here